Live attenuated vaccine trials in medically informed volunteers: a special case?

Live attenuated vaccine trials in medically informed volunteers: a special case?

A group of activist clinicians have offered to volunteer for clinical trials of live attenuated HIV vaccines. This has provided an important conceptual challenge to medical ethics, and to work on the development of HIV vaccines. In exploring these issues, this article highlights how the HIV field has altered the content as well as the tone of ethical discourse. The balance of expertise and auth...

A review of prophylactic measure against brucellosis in human with a live attenuated vaccine

Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran

Evaluation in volunteers of a candidate live oral attenuated Salmonella typhi vector vaccine.

Candidate vector vaccine strain CVD 906 (aroC- and aroD- derivative of virulent Salmonella typhi strain ISP1820) was evaluated in phase 1 clinical trials. The first nine volunteers ingested a single dose of 5 x 10(7) CVD 906 bacilli. At this dose CVD 906 stimulates remarkable systemic and mucosal immune responses, inasmuch as 89% of volunteers developed marked serum antibody levels to S. typhi ...

Development of a New Live Attenuated Mumps Virus Vaccine in Human Deploid Cells